Detection performance and spectral quality are tightly linked to the sample management system employed to position the sample in the sensitive region of the RF coil, and to the quality of the materials used in fabrication of the sample containment device. Protasis/MRM CapNMR probes employ a NMR flowcell that is designed using the highest quality materials available. Shims are adjusted at the time of installation to accommodate this geometry. Minor modification to the shim settings is typically required when switching from one solvent to another, or when highly salty buffers are employed, but is generally not required when simply changing samples in a common solvent. The Protasis/MRM design and selection of high quality materials results in high chemical compatibility, high filling factor, high S/N, excellent spectral resolution, and clean baselines. Whereas the CapNMR probe flow-loads the sample into the NMR flowcell, tube-based probes require the sample to be first flow-loaded (via liquid handler or other automation robot) into a tube. The tube is then mechanically moved into the probe and positioned in the center of the RF detection coil. Newer tube geometries employ susceptibility-matched glass to minimize the amount of sample that is required outside the active volume of the detection coil, and precision-machined walls that minimize variations in magnetic field homogeneity due to geometric imperfections and asymmetries. This means that the attributes of chemical compatibility, S/N, spectral resolution, and clean baselines in tube probes requires not one well-designed sample container for all samples, but rather one for each individual sample. This means that your costs scale with the number of samples. Considering that susceptibility-matched NMR tube sets can cost from $100 to over $300 per tube, this results in an enormous financial overhead for running the equivalent of a 96-well plate of samples. Most alternative analytical detection techniques have migrated from tubes to flow. Protasis/MRM has worked to integrate these principles and approaches into capillary-scale NMR. Without sacrificing performance, you are able to get your data more efficiently and with less cost. This means more competitive business practice, and allows you to focus your resources on getting more information to make decisions, rather than on more glassware to run the samples. Another way that capillary NMR just makes sense.