Significant effort has been expended in the past decade to incorporate means of chemical purification prior to NMR detection, in an attempt to isolate the analyte of interest and to eliminate unwanted “noise” from the NMR spectrum. Of the wide array of analytical methods that have been employed, the most popular NMR hyphenation has involved high performance liquid chromatography (HPLC). HPLC columns have been used to separate complex mixtures in order to isolate specific analytes for subsequent NMR investigation, and less aggressive forms of solid phase media (e.g. solid phase extraction cartridges) have been employed to concentrate analytes of interest and thereby maximize the desired (analyte) signal relative to the unwanted (solvent) signal in the NMR spectrum, i.e. to provide a high signal-to-solvent ratio. Considering the large proton abundance (typically molar concentration) in solvents relative to that (typically millimolar or less) in analytes, concentration of the analyte minimizes the challenges associated with solvent suppression and generally provides cleaner NMR baselines. The same concept applies to the condition of small mass analysis. While some larger-volume (e.g. cryo technology) probes boast of comparable mass sensitivity to microcoils, the use of such probes requires that the small analyte mass be dissolved into a relatively large volume of solvent. This approach results in a low signal-to-solvent ratio, and generally results in a NMR spectrum that is complicated by solvent and impurity artifacts. While the use of deuterated solvents and ultra-pure reagents helps to reduce unwanted artifacts, this truth applies equally to microcoils and larger volume applications. The simplest and most efficient approach is to maintain a high analtye concentration and to utilize clean, deuterated solvents. This is the approach used by the CapNMR probe.