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High Throughput
Natural Products |
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Discovery chemists might have the world's supply of a novel molecule
in a single microplate well. The ability to obtain complete
spectra from a single drop using capillary NMR lets them work faster
with the material they have, without going back to the rain forest
or ocean floor to get more. But with millions of possibilities
out there, these discovery researchers need reliable automation to
keep pace with the demands of their search. |
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MicroSynthesis with
Structure Confirmation
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Once you've found a promising natural or rational lead, you'll need
to synthesize it and possibly hundreds of variations. The
reagent and time cost of all of these combinations can be
prohibitive. Increasingly, Discovery researchers are scaling
down. One-Minute NMR can confirm these synthesis products quickly and
efficiently without only tiny amounts of valuable samples.
Even these small amounts can be recollected also. |
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HT-NMR
Screening |
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Screen for signs of activity using small amounts of
protein and ligand.
Perfect for finding strong binding candidates for further
screening. New Saturation Transfer Detection techniques work
by monitoring simple line broadening events on the ligand.
MicroFlow NMR requires the smallest volume of sample
(i.e., a few microliters) of any NMR technique. That means
you don't have to worry about taking too much from existing drug
lead libraries. And you can still recover all of your sample if
you need to.
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Metabolites with DFGF Pre-Concentration |
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Hepatocyte incubations are gaining more importance in the early
stages of metabolite investigations. Due to small incubation
size, however, the absolute amount of metabolite is limited and such
samples suggest themselves for analysis using the MicroFlow NMR
probe. The added use of fully deuterated solvents results in
higher spectral quality with the need for complex suppression. |
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[ View Application Note ]
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Trace
Impurities |
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Solvent peaks look like sequoias in the spectra from a conventional
volume probe. Put your trace analytes into a MicroFlow NMR
probe and their spectral features will 'pop' into focus. Our
solenoid coil architecture will give you better resolution and lower
noise. And the intrinsic high sensitivity of microcoils will
give you the highest mass sensitivity attainable. |
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Biofluids:
Human Serum and Urine |
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Research
interest in
diagnostic screening of serum and urine is increasing rapidly.
So is the number of samples. OneMinuteNMR breaks the speed
barrier holding NMR back in these emerging applications. A
single flowcell can process one thousand 1H-NMR spectra per day at
low cost/sample.. Need more? Get our dual flowcell probe
and double that. |
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Biofluids:
Sample-Limited Research |
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Most NMR research is constrained by the time or funds required to
collect or grow or synthesize sufficient sample. Now you can perform
metabonomics
on a single drop of mouse urine. Or
get spectra from fifty fireflies
instead of five hundred. Imagine the new studies you could do
if you were not worried about the amount of sample required.
Get published faster! |
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Efficient NMR Automation.
One-Minute NMR |
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