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"For quality
control of chemical libraries, 1D NMR spectra are acquired
under full automation from 384-well plates on as many as 130
compounds within 24 hours using 128 scans per spectrum and a
sample-to-sample cycle time of about 11 min. Because of the
low volume requirements and high mass sensitivity of the
microflow NMR system, 30 nmol of a typical small molecule is
sufficient to obtain high quality, well-resolved, 1D proton or
2D COSY NMR spectra in approximately 6 or 20 min of data
acquisition time per experiment, respectively."
"Because of the
high mass sensitivity and low sample consumption of the
One-Minute microflow NMR system, and because it can use D 2O
or nearly any solvent while still being economical, the
automated microflow system described and characterized here
also has great potential for metabolite evaluation, and other
applications of biological interest."
Bernhard
Geierstanger,
Genomics Institute of the Novartis Research Foundation
from
Anal. Chem. 2005,
------------------
"The active volume of the flow
cell is 3µL, compared with 0.5 mL in a conventional probe.
‘The procedure is different but very simple,’ said Schroeder.
‘Capillary NMR offers similar sensitivity to cryo probes but
at considerably lower cost and without the technically
challenging cryo support system of supercooled helium gas.
Further design refinements will lead to additional sensitivity
increases.'"
Frank Schroeder,Cornell
University
RSC: Chemistry World 2005,
July 25 |
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“An analysis of biofluids (blood, urine, cell
extracts, etc.) provides a snapshot of
the biological processes of an
individual that can be used in applications from diagnostics
to drug efficacy and toxicity. The Protasis/MRM capillary NMR
automation system is an essential component of Novatia’s
biofluid NMR analysis package and allows us to provide a
unique service to the research community.”
"As a contract laboratory with hundreds of samples in backlog, we
needed a way to get the most out of our available magnet time.
We purchased OneMinuteNMR because it is the best and most cost-effective NMR automation system available."
D.
Detlefsen, Novatia
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